Treatment of Hereditary Angioedema

Treatment of Hereditary Angioedema: Replacement therapy or immune modulating medicines pertaining to hereditary angioedema.

Generic Name

Brand Name

Use

Berotralstat

Orladeyo

Orladeyo Website

2 years and above as prophylaxis for hereditary angioedema

C1 Esterase Inhibitor (recombinant)

Ruconest

Ruconest Website

Acute angioedema in hereditary angioedema

C1 Inhibitor (human)

Berinert

Berinert Website
 

Acute attacks of hereditary angioedema

Intravenous medication to treat acute attacks of hereditary angioedema.

Cinryze

Cinryze Website
 

To prevent angioedema due to C1 esterase inhibitor deficiency.

Intravenous medication to prevent angioedema due to C1 esterase inhibitor deficiency.

Haegarda

Haegarda Website

Subcutaneous medication to prevent angioedema due to C1 esterase inhibitor deficiency.

Donidalorsen

Dawnzera

Dawnzera Website

Indicated for prophylaxis to prevent attacks of hereditary angioedema (HAE) in adult and pediatric patients 12 years of age and older. The dose is 80 mg administered subcutaneously every 4 weeks.

Ecallantide
Boxed Warning*

Kalbitor

Kalbitor Website

Acute treatement of angioedema.

From C1 esterase inhibitor  deficiency.

Three injections.

Garadacimab

Andembry

Andembry Website

For prophylaxis of hereditary angioedema (type 1 and type 2).

12 years and above 400 mg loading dose followed by 200 mg subcutaneous every month.

Icatibant

Firazyr

Firazyr Website

Acute attacks of hereditary angioedema- can be self-administered

1 dose with onset of attack, can repeat in 6 hours, no more than 3 doses in 24 hrs

Lanadelumab

Takhzyro

Takhzyro Website

For prophylaxis of hereditary angioedema (type 1 and type 2).

2-5 years 150 subcutaneous every 4 weeks.

6-11 years 150 mg subcutaneous every 2 weeks; consider every 4 weeks after 6 months.

12 years and above 300 mg subcutaneous every 2 weeks; consider every 4 weeks after 6 months.

Sebetralstat

Ekterly

Ekterly Website

An oral on-demand therapy to treat hereditary angioedema (HAE) attacks in adults and children 12 years of age and older.