A 46 year-old man with h/o oral allergy syndrome hospitalized 12/2017 for throat closing after one day of fever and sore throat treated with Dayquil and Motrin. In ED uvular edema was seen - admitted and treated with steroids, antihistamines, H2 blockers with improvement. Since then has had recurrent episodes of swelling of cheek or lips, eyes - in one episode he had a large urticarial lesion under his arm. All other episodes were only angioedema- usually resolve in 1-2 days with medication. Still having symptoms despite multiple antihistamines and is steroid dependent to prevent attacks. All labs and wu have been neg - HAE wu, including C1q, SPEP, eosinophil count, tryptase, alpha-gal, thyroid studies, RAST to foods. Would you try Xolair or meds for HAE such as icantibant?