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New Study Predicts Reactions to Peanut Oral Immunotherapy in Preschoolers

AAAAI News Release

April Presnell
AAAAI Executive Office: (414) 272-6071

February 1, 2022

Data from the 2022 AAAAI Annual Meeting finds characteristics that predict higher grades of reactions during peanut oral immunotherapy.

Milwaukee, WI – New predictors of safety for peanut oral immunotherapy (OIT) in preschoolers will help physicians develop a personalized approach to OIT safety, according to a recent study that will be presented at the 2022 Annual Meeting of the American Academy of Allergy, Asthma & Immunology (AAAAI).

“Shared decision-making between healthcare providers and families is essential when it comes to OIT, and the results of this study should make predicting OIT reactions a little bit easier,” said Edmond S. Chan, MD, FAAAAI, co-author of the study. “Our modeling includes not only starting age of the patient, but starting doses and duration of build-up.”

Researchers analyzed data from the Canadian Food Allergy Immunotherapy Registry for the study, which included 672 preschoolers. Authors used multivariate logistic regression modeling with the maximum grade of reaction, which was grade two or higher, versus grade one or no reaction, as the outcome.

Predictors analyzed included sex, age, reaction grade before the patient underwent OIT, atopic conditions, sIgE level, skin prick test size, time spent on OIT, the OIT starting dose and minimum dose eliciting symptoms during OIT. 35.7% of preschoolers in the dataset had a grade two or higher reaction, and 1.19% had a grade four reaction during OIT. The multivariate model found that older age, higher baseline sIgE, a grade two or higher reaction pre-OIT and lower eliciting dose (i.e., the first dose during the build-up schedule which triggered symptoms) predicted a reaction of grade two or higher during OIT.

Visit to learn more about OIT. Research presented at the AAAAI Annual Meeting, February 25-28 in Phoenix, Arizona, is published in an online supplement to The Journal of Allergy and Clinical Immunology.

The American Academy of Allergy, Asthma & Immunology (AAAAI) is the leading membership organization of more than 7,100 allergists, asthma specialists, clinical immunologists, allied health professionals and others with a special interest in the research and treatment of allergic and immunologic diseases. The AAAAI is the go-to resource for patients living with allergies, asthma and immune deficiency disorders. Established in 1943, the AAAAI has more than 7,100 members in the United States, Canada and 72 other countries. The AAAAI’s Find an Allergist/Immunologist service is a trusted resource to help you find a specialist close to home.