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Immunomodulator Allergy Medications

Last updated January 2024
 

Immunomodulator Medications: These medications act by directly changing the behavior of the immune system. The injectable forms are also known as biological medications or biologics.

Generic Name

Brand Name

Use

Abrocitinib

Boxed Warning*

Cibinqo

Oral Jak inhibitor (Janus kinase inhibitor)

https://www.cibinqo.com/

Used to treat adults with refractory moderate to severe eczema not responding to other therapies or when the use of other systemic therapies is inadvisable.

Benralizumab

Fasenra

Injection under the skin.

Fasenra Website

Add-on maintenance treatment for patients 12 and older with severe eosinophilic asthma.

Dupilumab

Dupixent

Injection under the skin

Dupixent Website

Uncontrolled moderate-to-severe eczema (atopic dermatitis) for those aged 6 months and older.

Add-on maintenance treatment for uncontrolled moderate-to-severe eosinophilic or oral steroid dependent asthma ages 6 and older.

Add-on maintenance treatment for uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP) aged 18 years and older.

To Treat Eosinophilic Esophagitis for those aged 12 years and older who weigh at least 88lb (40kg)

Mepolizumab

Nucala

Injection under the skin

Nucala Website

Add-on maintenance medication for patients 6 and older with severe eosinophilic asthma.

Add-on maintenance treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in adults 18 years and older.

For the treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome for ≥6 months without an identifiable non-hematologic secondary cause.

For the treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA).

Omalizumab
Boxed Warning*

Xolair

Injection under the skin

Xolair Website

Treats allergic asthma for adults and children 6 years and older.

Treats chronic idiopathic urticaria for adults and children 12 years and older.

Treats nasal polyps for adults 18 years and older.

Reslizumab
Boxed Warning*

Cinqair

Intravenous infusion

Cinqair Website

Add-on maintenance treatment of patients with severe asthma aged 18 years and older, and with an eosinophilic phenotype.

Tezepelumab-ekko

Tezspire

Injection under the skin

Tezspire Website

Add-on maintenance treatment of adult and pediatric patients aged 12 years and older with severe asthma.

Tralokinumab - ldrm

Adbry

Injection under the skin

https://www.adbryhcp.com/

Indicated for the treatment of moderate-to-severe atopic dermatitis in adult patients whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable

Upadacitinib
Boxed Warning*

Rinvoq

Oral Jak inhibitor (Janus kinase inhibitor)

https://www.rinvoq.com/

Used to treat children and adults > 12 years old with refractory moderate to severe eczema not responding to other therapies or when the use of other systemic therapies is inadvisable.

     
*Boxed Warning – this label indicates that the product, per the FDA, may have serious safety risks. Please speak with your health care provider or pharmacist to learn more about the potential side effects.

Find out more about skin allergies.