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Immunomodulator Medications: These medications act by directly changing the behavior of the immune system. The injectable forms are also known as biological medications or biologics.
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Generic Name
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Brand Name
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Use
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Abrocitinib
Boxed Warning*
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Cibinqo
Oral Jak inhibitor (Janus kinase inhibitor)
Cibinqu Website
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Used to treat adults with refractory moderate to severe eczema not responding to other therapies or when the use of other systemic therapies is inadvisable.
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Benralizumab
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Fasenra
Injection under the skin.
Fasenra Website
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Add-on maintenance treatment for patients 12 and older with severe eosinophilic asthma.
For the treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA).
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Dupilumab
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Dupixent
Injection under the skin
Dupixent Website
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Uncontrolled moderate-to-severe eczema (atopic dermatitis) for those aged 6 months and older.
Add-on maintenance treatment for uncontrolled moderate-to-severe eosinophilic or oral steroid dependent asthma ages 6 and older.
Add-on maintenance treatment for uncontrolled chronic rhinosinusitis with nasal polyposis (CRSwNP) aged 18 years and older.
To treat eosinophilic esophagitis for those aged 1 year of age and older with certain weight restrictions.
Treatment for patients with chronic spontaneous urticaria (CSU) ages 12 years and up who continue to have hives that are not controlled with H1 antihistamine treatment.
Add-on maintenance treatment for adults with inadequately controlled chronic obstructive pulmonary disease (COPD) with an eosinophilic phenotype.
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Lebrikizumab-lbkz
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Ebglyss
Injection under the skin
Ebglyss Website
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Indicated for the treatment of moderate-to-severe atopic dermatitis in adults and children 12 years of age and older who weigh at least 88 pounds (40 kg) whose disease is not adequately controlled with topical prescription therapies or who cannot use topical therapies.
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Mepolizumab
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Nucala
Injection under the skin
Nucala Website
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Add-on maintenance medication for patients 6 and older with severe eosinophilic asthma.
Add-on maintenance treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in adults 18 years and older.
For the treatment of adult and pediatric patients aged 12 years and older with hypereosinophilic syndrome for ≥6 months without an identifiable non-hematologic secondary cause.
For the treatment of adult patients with eosinophilic granulomatosis with polyangiitis (EGPA).
Add-on maintenance treatment for adults with inadequately controlled chronic obstructive pulmonary disease (COPD) with an eosinophilic phenotype.
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Nemolizumab-ilto
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Nemluvio
Injection under the skin
Nemluvi Website
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Indicated for the treatment of moderate-to-severe atopic dermatitis in adults and children 12 years of age and older whose disease is not adequately controlled with topical prescription therapies
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Omalizumab
Boxed Warning*
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Xolair
Injection under the skin
Xolair Website
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Treats allergic asthma for adults and children 6 years and older.
Treats chronic idiopathic urticaria for adults and children 12 years and older.
Treats nasal polyps for adults 18 years and older.
For the reduction of allergic reactions, including anaphylaxis, that may occur with accidental exposure to one or more foods in adult and pediatric patients aged 1 year and older who have IgE-mediated food allergy.
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Reslizumab
Boxed Warning*
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Cinqair
Intravenous infusion
Cinqair Website
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Add-on maintenance treatment of patients with severe asthma aged 18 years and older, and with an eosinophilic phenotype.
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Tezepelumab-ekko
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Tezspire
Injection under the skin
Tezspire Website
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Add-on maintenance treatment of adult and pediatric patients aged 12 years and older with severe asthma.
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Tralokinumab - ldrm
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Adbry
Injection under the skin
Adbry Webstie
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Indicated for the treatment of moderate-to-severe atopic dermatitis in adult patients whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable
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Upadacitinib
Boxed Warning*
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Rinvoq
Oral Jak inhibitor (Janus kinase inhibitor)
Rinvoq Webiste
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Used to treat children and adults > 12 years old with refractory moderate to severe eczema not responding to other therapies or when the use of other systemic therapies is inadvisable.
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