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Trends, characteristics, and incidence of anaphylaxis: A population-based study


Published Online: July 7, 2016

Anaphylaxis is a potentially life-threatening systemic allergic reaction. In the original research published in The Journal of Allergy & Clinical Immunology (JACI), Lee and colleagues aimed to determine the incidence rate and causes of anaphylaxis from the epidemiological cohort.

Authors utilized the resources of the Rochester Epidemiology Project, a comprehensive records linkage system, to conduct a population-based incidence study in Olmsted County, Minnesota, from 2001 through 2010. All cases with a diagnosis of anaphylactic shock and 20% of cases with related diagnoses were manually reviewed. The relationships of age group, sex, and year of anaphylaxis with incidence rates were assessed.

Six hundred thirty-one cases of anaphylaxis were identified. The median age was 31 years. The overall age- and sex-adjusted incidence rate was 42 per 100,000 person-years. There was a significant increase in the overall incidence of anaphylaxis during the study period, with an average increase of 4.3% per year. Especially, there was a 9.8% increase per year in the incidence rate of food-related anaphylaxis. Food-related anaphylaxis was most common in children aged 0 to 9 years, venom-related anaphylaxis was most common in those 20 to 39 years of age, and medication-related anaphylaxis was most common in those 30 to 39 years of age.

Author concluded that the incidence of anaphylaxis increased from 2001 to 2010, and food-related anaphylaxis in children, venom and medication-related anaphylaxis in young to middle adults were common.

The Journal of Allergy and Clinical Immunology (JACI) is an official scientific journal of the AAAAI, and is the most-cited journal in the field of allergy and clinical immunology.
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