Published Online: July 3, 2015
Hypercholesterolemia is known to increase the risk of cardiovascular diseases, but recently it has also been associated with a skewing of the immune system, which could mediate other diseases such as asthma and allergy. Only a few studies have examined the relationship between the blood lipid profile and asthma, but only few studies have been performed in children and no studies have investigated the relationship with lung function and allergic sensitization.
In an article recently published in The Journal of Allergy & Clinical Immunology (JACI), Vinding and colleagues examined whether the blood lipid profile is associated with concurrent asthma, altered lung function, and allergic sensitization in school-aged children. The lipid profile was measured at age 5-7 years in 296 children from the Danish Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000) birth cohort, followed from birth at the COPSAC research center, where diagnosis of asthma, rhinitis and sensitization was obtained.
The researchers analyzed the association between high- and low-density lipoprotein cholesterols (HDL-C and LDL-C), triglycerides, asthma, lung function, sensitization, and rhinitis adjusting for BMI, exposure to passive smoking, and gender. They found that high level of LDL-C was associated with asthma and airway obstruction, high level of HDL-C was associated with reduced airway obstruction and a decreased risk of aeroallergen sensitization, and high level of triglycerides was associated with a higher risk of aeroallergen sensitization.
These findings suggest a link between an offset blood profile and asthma and allergy in childhood. Such lipid profile has been associated with other common noncommunicable diseases and the authors propose that asthma and allergy are systemic disorders with commonalities with other chronic inflammatory disorders.
The Journal of Allergy and Clinical Immunology (JACI) is the official scientific journal of the AAAAI, and is the most-cited journal in the field of allergy and clinical immunology.