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X-Linked Agammaglobulinemia

X-Linked agammaglobulinemia (XLA) is an inherited immunodeficiency in which the body is unable to produce the antibodies needed to defend against bacteria and viruses.

Frequently called Bruton's Agammaglobulinemia, XLA is caused by a genetic mistake in a gene called Bruton's tyrosine kinase (BTK), which prevents B cells from developing normally. B cells are responsible for producing the antibodies that the immune system relies on to fight off infection.

The most common bacteria causing infection in XLA are Streptococcus, Staphylococcus and Haemophilus.

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