Mast cells are allergy cells that cause allergic symptoms by releasing products called “mediators” stored inside them or made by them. They are triggered to release these products in a process called “activation”. Usually mast cells are activated by known triggers such as allergic antibody, medications or infections. The released mediators go on to produce allergic symptoms such as sneezing, wheezing and itching. In more severe reactions such as anaphylaxis, the symptoms can be hives, swelling, low blood pressure, fainting, difficulty breathing, nausea and vomiting or profuse diarrhea.
Mast Cell Activation Syndrome (MCAS) is a condition in which the patient experiences repeated episodes of these symptoms but the trigger cannot be identified. The exact combination of symptoms and the organ systems affected can vary from patient to patient, but the cases are similar in the mast cell mediators that are released and the treatments that are effective.
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about Mast Cell Activation Syndrome symptoms, diagnosis, treatment and management.