Cookie Notice

This site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our cookies information for more details.

OK

Q:

6/22/2020
Is there a non-irritating skin test concentration for ustekinumab?

A:

Monoclonal antibodies, such as ustekinumab, resemble normal human immunoglobulin. Such molecules are not likely to be irritating to the skin other than due to high concentration causing an osmotic effect. I could not find any report of skin testing for specific-IgE in the literature. There are no preservatives in the product (1).

In summary, I am not aware of a non-irritating concentration of ustekinumab for skin testing. I would suggest using a 1:100 and 1:10 and full-strength concentration (90mg/ ml) for percutaneous and intradermal testing. If an apparent positive result occurs, I suggest testing ‘normal volunteers’, including yourself or other clinical staff. The positive or negative predictive value of such testing is not known.

1. http://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/STELARA-pi.pdf.

I hope this information is of help to you and your practice.
All my best.
Dennis K. Ledford, FAAAAI

Close-up of pine tree branches in Winter Close-up of pine tree branches in Winter