Q:

1/2/2018
If a patient has a history of anaphylaxis to lipitor, could they tolerate a different statin?

A:

I found 2 case reports related to your question. In 2013, Khan et al reported a case of successful desensitization to rosuvastatin in a patient with history of anaphylaxis to multiple statins, including atorvastatin. In 2015, Ogai et al reported a successful graded drug challenge to rosuvastatin and long term treatment with it in a patient with apparent simvastatin allergy. I have provided the references for these case reports.

References:
Khan FS et al, JACI 2013;131:234-5.
Ogai Ya et al, JACI: In Practice 2015;3:993-5.

Jacqueline A. Pongracic, MD, FAAAAI

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