Is there a difference in using whole sesame seeds (hulled) vs ground seeds for oral challenges, as long as the total amount of ingested protein is equivalent? Another allergist recently commented to a colleague that she would not use whole sesame seeds (did not specify hulled or not) for an oral challenge (and instead use ground seeds) because there are "different proteins inside and outside of the seed". And so, one could ingest the seeds, and seem fine, but as they digest the seeds, start having reactions (which may wax and wane as the digestion continues) - and gives an example of one of her patients to whom that happened. I had not heard this and she has not provided any references. I cannot find anything in my lit search. Based on what I see of sesame seeds, if they are hulled (as they typically are in the US), the "inside" should be accessible to the immune system readily, and not matter if whole or ground.