Cookie Notice

This site uses cookies. By continuing to browse this site, you are agreeing to our use of cookies. Review our cookies information for more details.

OK
skip to main content

Semaglutide skin testing for immediate hypersensitivity

Question:

3/3/2020
Are there any guidelines/recommendations for skin testing to ozempic for a reported hypersensitivity reaction (uvula angioedema)?

Answer:

If there has not been a local reaction at the site of previous semaglutide injections, then I would not recommend skin testing with semaglutide as part of a work-up to determine the cause of isolated uvula angioedema. Semaglutide is a peptide molecule with a molecular weight of 4113 daltons and is over 99% protein bound. If one was going to do skin testing, then I would recommend using 0.01 mg/mg, 0.1 mg/ml and 1 mg/ml, looking for a wheal > 5 mm with flare greater than wheal. One would also need to document that these concentrations are not irritating in normal controls.

Eric Macy, MD, MS, FAAAAI