Semaglutide skin testing for immediate hypersensitivity
Question:
3/3/2020
Are there any guidelines/recommendations for skin testing to ozempic for a reported hypersensitivity reaction (uvula angioedema)?
Answer:
If there has not been a local reaction at the site of previous semaglutide injections, then I would not recommend skin testing with semaglutide as part of a work-up to determine the cause of isolated uvula angioedema. Semaglutide is a peptide molecule with a molecular weight of 4113 daltons and is over 99% protein bound. If one was going to do skin testing, then I would recommend using 0.01 mg/mg, 0.1 mg/ml and 1 mg/ml, looking for a wheal > 5 mm with flare greater than wheal. One would also need to document that these concentrations are not irritating in normal controls.
Eric Macy, MD, MS, FAAAAI