I saw an elderly gentlemen with lip/facial angioedema. He states if he takes an erectile dysfunction med (either viagra, levitra, or cialis), he wakes up with angioedema at 4 am. If he takes the med, has sex, then takes benadryl, he doesn't have the angioedema. He says this is a consistent finding. He is on metoprolol, aspirin 81 mg, and vitamins. Complement studies are normal. I searched the Annals and JACI and couldn’t find any articles about this. Have you heard of this and what to do?