Leucovorin, irinotecan, and oxaliplatin skin testing
Question:
3/3/2020
Do you have skin testing concentrations for leucovorin, irinotecan and oxaliplatin?
Answer:
IgE-mediated allergy has not been described with leucovorin and thus skin testing will not be useful.
Skin testing is possible to irinotecan at the concentrations described by Alvarez-Cuesta et al [J Investig Allergol Clin Immunol 2016; Vol. 26(5): 314-343]: prick test, 20 mg/mL, and intradermal tests, 2 mg/mL and 20 mg/mL.
Skin prick testing with oxaliplatin 0.5 mg/mL.
Intradermal testing with oxaliplatin at 0.05 mg/mL, 0.5 mg/mL, and up to 5 mg/mL if the skin tests are negative at the lower concentrations.
J Allergy Clin Immunol Pract. 2014 Jan-Feb;2(1):40-5.
Eric Macy, MD, MS, FAAAI