Q:

9/4/2012
If I am giving a placebo shot to test whether or not an unusual reaction of delayed abdominal pain is the result of immunotherapy, how much histamine should I mix into a .5cc mix so the patient can't tell it's placebo.

A:

Thank you for your inquiry.

The concentration of histamine phosphate usually employed for placebo controls during immunotherapy is 0.01 mg per ml. This concentration can be obtained by dilution of the commonly available concentration of 1 mg per ml.

Thank you again for your inquiry and we hope this response is helpful to you.

Sincerely,
Phil Lieberman, M.D.

AAAAI - American Academy of Allergy Asthma & Immunology