We sought the expert opinion of Dr. Rothenberg. See his response below.
For Eosinophilic Esophagitis, there is no evidence that skin prick testing or serum food-specific IgE are valuable for guiding dietary therapy. This is likely related, at least in part, to the high level of IgG4, which counters IgE. If however, an EoE patient has co-existing food anaphylaxis, then there would be value of skin and serum testing, related to the anaphylaxis (not EoE).
Marc E. Rothenberg MD, PhD
Thank you for the question.
Patricia McNally, MD, FAAAAI