I have been asked to consult on a patient with Crohn's disease for possible Humira (adalimumab) desensitization. She has had angioedema of the tongue and urticaria after receiving this medication in the past, and has had a similar reaction to Remicade. She has had numerous other trials of other medications, which have not been effective, including Enbrel, Imuran, dapsone, colchicine, and others. I am aware that protocols exist for desensitization to monoclonal antibodies, but have not seen Humira referenced specifically in these. I did try to review Dr. Castell's book chapter that you have mentioned in previous similar posts, but it's at this time only available online in portions (i.e. most pages are not able to be viewed). Thanks for your help.