By definition, individuals with common variable immunodeficiency fail to mount effective antibody responses. There are no anti-COVID-19 antibodies in the current intravenous gammaglobulin preparations. Individuals with common variable immunodeficiency tend to do fairly well with COVID-19 infections. The vaccine in this setting is mainly stimulating anti-COVID-19 T cell immunity. She should follow the standard guidelines that any COVID-19 vaccinated person is encouraged to follow.
I hope this information is helpful for you and your patient.
Eric Macy, MD, MS, FAAAAI