I was recently consulted on71 year old male who has had bypass surgery and is on Plavix for 12 years. He has history of hives to Aspirin, because of frequent bleeding with shaving and minor cuts he want to undergo Aspirin desensitization, if we desensitization what minimum Aspirin dose will be sufficient to maintain desensitization so that he does not have bleeding.


Thank you for your inquiry.

You do not have to reach a specific dose to maintain desensitization. You will maintain desensitization at whatever dose you reach. This is true as long as you take it daily. If you discontinue aspirin, then you become sensitized again.

Normally, a dose of 81 to 162 mg is sufficient to maintain a state of anticoagulation for coronary purposes. At least that is the dose that the cardiologists we work with think is sufficient. Therefore, provided your cardiologists are in agreement, a desensitization to that dose and the continued maintenance dosing would be sufficient.

Thank you again for your inquiry and we hope this response is helpful to you.

Phil Lieberman, M.D.

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