Three-Injection Immunotherapy for Grass Pollen Well Tolerated in Teens
Three ultrasound guided lymph node injections safe in teens
Houston, TX – Researchers have new evidence that grass-pollen allergies can be safely treated using American extracts injected into a lymph node (intralymphatic immunotherapy or ILIT).
ILIT treatments, which require only three injections and target specific lymph nodes, have already demonstrated their safety and efficacy in European trials involving adults.
“We wanted to explore the treatment using extracts commercially available in the United States,” explained Amber M. Patterson, MD, first author.
Clinicians enrolled 15 teens to complete the grass-pollen ILIT trials in a randomized, double-blind, placebo controlled pilot trial and assigned total safety scores by assessing the patients for adverse events two hours, five hours, and one week after each injection.
“ILIT injections were remarkably well-tolerated, and parents appreciated the convenience of only three injections to treat their children’s allergies,” according to Patterson.
Extracts were administered into the right, inguinal (groin) lymph node by ultrasound during three visits, each at least four weeks apart. Treatment consisted of escalating doses of grass pollen extract or saline.
All participants completed the injections and there was no difference in total safety scores between active treatment and placebo groups.
“This could revolutionize immunotherapy treatments by offering a convenient and safe option for our patients who have difficulty adhering to the traditional allergy shot schedule,” Patterson explained.
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The AAAAI represents allergists, asthma specialists, clinical immunologists, allied health professionals and others with a special interest in the research and treatment of allergic and immunologic diseases. Established in 1943, the AAAAI has more than 6,800 members in the United States, Canada and 72 other countries. The AAAAI’s Find an Allergist/Immunologist service is a trusted resource to help you find a specialist close to home.