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Cells that Protect: Lymphocytes, Neutrophils/Granulocytes and Monocytes/Macrophages

Problems with neutrophils related to PIDD include:
•    Neutropenia
•    Chronic Granulomatous Disease (CGD)

Monocytes/macrophages circulate in the blood and become macrophages in the tissues. These cells are very important in alerting the immune system about an infection. Macrophages are scavengers whose job is to engulf or eat up infecting germs and even infected cells. Macrophages also help to overcome infection by secreting signals that help activate other cell types to fight against infections.

Problems with macrophages may involve disorders in the interleukin-12 (IL-12) or interferon-gamma pathways.

Learn more about PIDD.

This article has been reviewed by Andrew Moore, MD, FAAAAI

Reviewed: 9/28/20