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New Research - August 2009
Cochran Reviews, long-acting beta agonists in children
Summary
This Cochran review looked at the use of a long-acting beta-agonist (LABA) as adjunctive therapy to inhaled corticosteroids in children. They found the following:
- The addition of a LABA did not significantly reduce the risk of exacerbation requiring systemic steroids.
- A LABA did improve lung function compared to ongoing treatment with a similar dose of inhaled corticosteroid and, compared to doubling the dose of inhaled corticosteroid, the addition of a LABA still improved lung function.
- The addition of a LABA led to greater growth compared to doubling the dose of inhaled steroid.
- Compared to doubling the dose of an inhaled steroid, the addition of a LABA did not reduce the rate of moderate exacerbations or hospital admissions.
- There was no evidence of increased serious side effects associated with the addition of a LABA.
Reference
Chroinin MN, et al. Cochran Reviews, 7/09/09.
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