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New Research - April 2009
Patients with C1 inhibitor deficiency syndrome have evidence for activation of clotting and clot lysis during asymptomatic phases which increases during episodes
During episodes of angioedema in patients with C1 inhibitor deficiency syndrome (both the acquired and hereditary forms),coagulation and fibrinolytic pathways are activated. The authors desired to see whether markers of coagulation and fibrinolysis could be used to assist in the diagnosis of inhibitor deficiency syndromes.
They therefore measured prothrombin fragment F1 + 2 (marker of thrombin generation) and D-dimer (marker of fibrin degradation) in patients with C1 inhibitor deficiency syndrome, both in an asymptomatic state and during episodes of angioedema. They compared these results with patients having abdominal colic and with healthy subjects.
A total of 28 patients with C1 inhibitor deficiency syndrome were enrolled. They found that plasma F1 + 2 levels were higher in patients with C1 inhibitor deficiency during remission than in healthy controls, and further increased during attacks. The same was seen for plasma D-dimer levels.
They concluded that patients with C1 inhibitor deficiency syndrome have higher baseline levels of prothrombin factor F1 + 2 and D-dimer levels which further increase during episodes.
Reference
Cogno M, et al. Plasma biomarkers of acute attacks in patients with angioedema due to C1 inhibitor deficiency. Allergy 2/2/2009, online.
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