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New Research - April 2009
Effect of corticosteroids and long-acting beta-agonists on fibronectin and tenascin-C production in cultured fibroblasts
Airway remodeling is characterized by the deposition of extracellular matrix proteins within the lung. Two of these are fibronectin and tenascin-C. The investigators in this study desired to assess the effect of fluticasone and salmeterol on the deposition of these substances.
They used fibroblasts cultured in serum-free medium.
Fluticasone increased fibronectin transcription and decreased tenascin-C transcription. Salmeterol had no effect on either fibronectin or tenascin-C.
Reference
Degen M, et al. Opposite effect of fluticasone and salmeterol on fibronectin and tenascin-C expression in human lung fibroblasts. Clinical and Experimental Allergy 2009; 39(5):688-699.
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