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Patients & Consumers Conditions En Español Find an Allergist / Immunologist Just for Kids New Research Parent Resources Pollen Levels Publications Request a Speaker School Tools Seniors The Virtual Allergist™ Treatments Donate Now Search by Condition (A-Z) Search by Topic Allergy & Asthma Issues Educational Brochures Elements of Allergy and Asthma Order Public Education Materials Allergy Shots Drug Guide Sublingual Immunotherapy (SLIT)		New Research - March 2009 Peripheral T-cell function is exaggerated and abnormal in patients with COPD and correlates with disease severity The authors evaluated peripheral T-cell markers and function in patients with COPD. Patients with emphysema had less CD4 T-cells producing IL-10. On the other hand, the CD8 T-cells from COPD patients were more often activated, producing both IFN-gamma and IL-4. The severity of the COPD was inversely associated with circulating CD4 T-cells as well as the frequency of CD8 T-cell activation and CD8 interferon gamma production. The authors concluded that circulating T-cells from COPD patients are abnormally activated, elaborating pro-inflammatory mediators that consisted of a mixture of both Th1 and Th2 responses. These abnormal responses were correlated with disease severity. Reference Xuehai Zhu, et al. Peripheral T-cell functions correlate with the severity of chronic obstructive pulmonary disease. Journal of Immunology, 2009; 182:3270-3277. <back>
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