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Patients & Consumers Conditions En Español Find an Allergist / Immunologist Just for Kids New Research Parent Resources Pollen Levels Publications Request a Speaker School Tools Seniors The Virtual Allergist™ Treatments Donate Now Search by Condition (A-Z) Search by Topic Allergy & Asthma Issues Educational Brochures Elements of Allergy and Asthma Order Public Education Materials Allergy Shots Drug Guide Sublingual Immunotherapy (SLIT)		New Research - March 2009 Cross reactive antigenic determinants present in both Vespula venom and bee venom The authors wished to investigate whether or not the commonly noted simultaneous occurrence of sensitivity to both bee and Vespula venom seen on skin testing was due to a separate sensitivity to both venoms or to cross-reacting allergens. They performed in vitro testing to bee and Vespula venom in 100 patients who had experienced allergic reactions to either Vespula or honeybee stings, and who had positive skin tests to these venoms. Fifty-nine percent of patients demonstrated positive in vitro tests by Unicap testing to both bee and Vespula venom. Utilizing ADVIA centaur in vitro testing, 32% had positive tests to both venoms. They concluded that the simultaneous sensitivity to both venoms was not due to a separate sensitivity to each venom, but rather due to cross-reactive antigens present in both. These cross-reactive antigens were carbohydrate determinants. Reference Muller UR, et al. Hymenoptera venom allergy: analysis of double positivity to honeybee and Vespula venom by estimation of IgE antibodies to species specific major allergens Api M1 and Ves v5. Allergy 2009; 64(4):543-548. <back>
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