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New Research - March 2009Chemokine CC-Ligand 5, eosinophilic cationic protein, cysteinyl leukotrienes are increased by nasal exposure to aspirin in aspirin-sensitive asthmatics with rhinosinusitis but not aspirin-tolerant patients with asthma and rhinosinusitisThe investigators studied aspirin-sensitive patients for the production of CC-Ligand 5 (CCL5) and its association with eosinophil activation in the upper airways. Twenty aspirin-sensitive asthma/rhinosinusitis patients, 18 atopic aspirin-tolerant patients with asthma and rhinosinusitis, and 15 control subjects were evaluated. Nasal challenges with lysine-acetylsalicylic acid (L-ASA) intranasally. Nasal lavage was obtained at a baseline and two hours after challenge. Baseline levels of CCL5 were significantly increased in both the aspirin sensitive and tolerant groups. No significant differences were seen between these two groups. L-ASA nasal challenge significantly increased levels of CCL5 in ASA-sensitive patients, but not in ASA-tolerant subjects or controls. The same was found for eosinophilic cationic protein (ECP) and cysteinyl leukotrienes (cys-LTS). In vitro incubation of nasal tissue with aspirin produced increased levels of CCL5 in aspirin-sensitive but not aspirin-tolerant subjects. The authors concluded that CCL5 as well as ECP and cys-LTS production is enhanced by aspirin challenge in aspirin-sensitive, but not aspirin-insensitive asthmatics and rhinosinusitis patients. ReferenceFuentes-Beltran A, et al. Chemokine CC-Ligand 5 Production and Eosinophil Activation into the Upper Airways of Aspirin-Sensitive Patients. Clinical and Experimental Allergy 2009; 39(4):491-499. |
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