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Patients & Consumers Conditions En Español Find an Allergist / Immunologist Just for Kids New Research Parent Resources Pollen Levels Publications Real Life Stories Request a Speaker School Tools Seniors The Virtual Allergist™ Treatments Search by Condition (A-Z) Search by Topic Allergy & Asthma Issues Educational Brochures Elements of Allergy and Asthma Order Public Education Materials Washington Post Supplement Allergy Shots Drug Guide Sublingual Immunotherapy (SLIT)		SELECTED ARTICLES FROM THE RECENT LITERATURE 2008 7/9/2008 A World Allergy Organization Statement Regarding the Use of Epinephrine for Treatment of Anaphylaxis Summary There has been a great deal of discussion in the literature regarding the potential of vasopressin, added to epinephrine, in resuscitation protocols. Although these data may not apply specifically to anaphylactic patients, they do perhaps give us some hint as to whether or not vasopressin might be useful in patients experiencing severe episodes of anaphylactic shock. There has been controversy in the past as to whether or not the addition of vasopressin would be superior to epinephrine alone. The investigators involved in this study intended to answer the question as to whether the addition of vasopressin would be helpful in this population. To do so, they designed a multicenter study in which 1 mg of epinephrine and 40 IU of vasopressin was compared with 1 mg of epinephrine and saline placebo. The primary endpoint was survival to hospital admission. The secondary endpoints were return of spontaneous circulation, survival to hospital discharge, good neurologic recovery, and one year survival. They found that, "As compared with epinephrine alone, the combination of vasopressin and epinephrine during advanced cardiac life support does not improve outcome." Reference Gubugniaud P, et al. Vasopressin and epinephrine versus epinephrine alone in cardiopulmonary resuscitation. New England Journal of Medicine 2008; 359:21-30.   Back
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