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SELECTED ARTICLES FROM THE RECENT LITERATURE 2008

10/23/2008

Immunizations and the risk of atopic disease

Summary
The authors of this investigation followed 2,184 infants, age one to two years, with atopic dermatitis and a family history of allergy from 97 centers in 10 European countries, South Africa, and Australia.

The object was to see if there was a relationship between vaccine administration (diphtheria, tetanus, pertussis, polio, haemophilus influenza, hepatitis B, mumps, measles, rubella, varicella, BCG, meningococci, and pneumococci) and severity of atopic eczema as assessed by SCORAD. They also measured IgE.

They found that immunization was not related to the risk for allergic sensitization to foods or inhalants. Varicella immunization was inversely associated with total IgE and eczema severity. Pertussis immunization was inversely associated with eczema severity. Cumulative vaccine doses were inversely associated with eczema severity.

They concluded that common childhood immunization during the first year of life was not associated with an increased risk for eczema severity or allergic sensitization.

Reference
Gruber, et al. Early atopic disease and early childhood immunization - is there a link? In: Allergy 2008; 63(11):1464-1472.

 

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