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Patients & Consumers Conditions En Español Find an Allergist / Immunologist Just for Kids New Research Parent Resources Pollen Levels Publications Real Life Stories Request a Speaker School Tools Seniors The Virtual Allergist™ Treatments Search by Condition (A-Z) Search by Topic Allergy & Asthma Issues Educational Brochures Elements of Allergy and Asthma Order Public Education Materials Washington Post Supplement Allergy Shots Drug Guide Sublingual Immunotherapy (SLIT)		SELECTED ARTICLES FROM THE RECENT LITERATURE 2008 10/06/2008 In vitro glucocorticoid response in asthma is reduced in obese patients Summary The investigators of this paper studied asthma in adult subjects for loss of lung function, body mass index, spirometric response to prednisone, dexamethasone induced mitogen-activated protein kinase phosphatase-1 (MKP-1) and baseline tumor necrosis factor-alpha (TNF-alpha) expression. A total of 45 nonsmoking adults, 33 of whom had asthma, were evaluated. They also determined the relationship between BMI and MKP-1 and TNF-alpha expression. They demonstrated an inverse relationship between body mass index and the ability of dexamethasone to induce MKP-1 expression. They concluded an elevated BMI is associated with a diminished in vitro response to dexamethasone in overweight and obese patients with asthma. Reference Sutherland ER, et al. Body mass and glucocorticoid response in asthma. American Journal of Respiratory and Critical Care Medicine 2008; 178:682-687.   Back
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