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Patients & Consumers Conditions En Español Find an Allergist / Immunologist Just for Kids New Research Parent Resources Pollen Levels Publications Real Life Stories Request a Speaker School Tools Seniors The Virtual Allergist™ Treatments Search by Condition (A-Z) Search by Topic Allergy & Asthma Issues Educational Brochures Elements of Allergy and Asthma Order Public Education Materials Washington Post Supplement Allergy Shots Drug Guide Sublingual Immunotherapy (SLIT)		SELECTED ARTICLES FROM THE RECENT LITERATURE 2008 10/10/2008 Peanut allergic patients can have cross-reacting antibodies to sprouts Summary The authors of this investigation evaluated seeds and sprouts for allergens that might cross react with peanuts. They evaluated peanuts, soybeans, green peas, blue lupine, mung bean, alfalfa, broad bean, and azuki bean. They evaluated 10 peanut-allergic patients analyzing indirect histamine release, enzyme-allergosorbent test, allergosorbent inhibition, and Western blots. Also skin tests were performed on the patients with fresh legume seeds and four commercial legume sprouts. Food challenges were carried out with soybean, pea, and lupine in a subgroup of patients. They found that all legume seeds and commercial sprouts induced positive skin test responses in some of the patients. Indirect histamine release experiment showed an extensive cross-reactivity between peanut and legumes, and cross-reactivity was also noted for soybean, pea, and lupine seeds in enzyme-allergosorbent tests. Of the 16 protein extracts, soybean, pea, and lupine seeds produced visible bands in Western blots. The authors concluded that symptoms in peanut allergic patients after legume sprout ingestion could be caused by cross-reacting peanut-specific IgE. Reference Jensen LB, et al. Peanut cross-reacting allergens in seeds and sprouts of a range of legumes. In: Clinical and Experimental Allergy 2008; 38(12):1969-1977.   Back
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