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SELECTED ARTICLES FROM THE RECENT LITERATURE 2008

10/06/2008

Churg-Strauss Syndrome and chronic eosinophilic pneumonia: distinguishing features

Summary
The differential diagnosis between chronic eosinophilic pneumonia in an asthmatic and Churg-Strauss can be difficult, and Churg-Strauss is often preceded by chronic eosinophilic pneumonia. The authors therefore wished to be able to identify features that might distinguish eosinophilic pneumonia in the asthmatic from Churg-Strauss. To do that, they looked at the role of regulatory T cells in these diseases.

They evaluated 38 patients with Churg-Strauss and 20 with chronic eosinophilic pneumonia. They looked at the number of CD4 + CD25 + T cells in peripheral blood, and several cytokines. They found that patients with Churg-Strauss had significantly fewer CD4 + CD25 + T cells than did those with chronic eosinophilic pneumonia.

They concluded that the "maintenance of the numbers of regulatory T cells in patients with chronic eosinophilic pneumonia and asthma might inhibit the development of Churg-Strauss."

Reference
Tsurikisawa N, et al. Differences in regulatory T cells between Churg-Strauss Syndrome and chronic eosinophilic pneumonia with asthma. Journal of Allergy and Clinical Immunology; Volume 122 (Number 3), September 2008, pages 610-616.

 

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