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Patients & Consumers Conditions En Español Find an Allergist / Immunologist Just for Kids New Research Parent Resources Pollen Levels Publications Real Life Stories Request a Speaker School Tools Seniors The Virtual Allergist™ Treatments Search by Condition (A-Z) Search by Topic Allergy & Asthma Issues Educational Brochures Elements of Allergy and Asthma Order Public Education Materials Washington Post Supplement Allergy Shots Drug Guide Sublingual Immunotherapy (SLIT)		SELECTED ARTICLES FROM THE RECENT LITERATURE 2008 8/31/2008 Small Particle Corticosteroid Inhalers Can Improve Small Airway Performance in Asthma Summary The investigators evaluated 16 mild to moderate asthma patients with the following: Mean forced expiratory flow between 25 and 75% of forced vital capacity, percentage fall in forced vital capacity with administration of adenosine-5-monophosphate and methacholine causing a 20% fall in FEV1, CT scans before and after methacholine challenge, single breath nitrogen closing volumes, and alveolar exhaled nitric oxide. Seven subjects received placebo and nine ciclesonide. The ciclesonide group demonstrated improvements in exhaled alveolar nitric oxide and CT measurements of expiratory lung volume after methacholine challenge. There was no difference between ciclesonide and placebo treated groups in other measured parameters. The authors concluded that "inflammation and patency of small airways, reflected by alveolar exhaled nitric oxide and air trapping on CT scan," both improve with ciclesonide." Reference Cohen J, et al. Ciclesonide improves measures of small airways involvement in asthma. European Respiratory Journal 2008; 31:1213-1220.   Back
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