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Patients & Consumers Conditions En Español Find an Allergist / Immunologist Just for Kids New Research Parent Resources Pollen Levels Publications Real Life Stories Request a Speaker School Tools Seniors The Virtual Allergist™ Treatments Search by Condition (A-Z) Search by Topic Allergy & Asthma Issues Educational Brochures Elements of Allergy and Asthma Order Public Education Materials Washington Post Supplement Allergy Shots Drug Guide Sublingual Immunotherapy (SLIT)		SELECTED ARTICLES FROM THE RECENT LITERATURE 2008 10/9/07 Assessment in clinical interpretation of reduced IgG values Summary The authors studied hypogammaglobulinemia in children under 2 years of age. Thirty-four patients were evaluated and 10 of these were found to be atopic. In 5 of the 10 patients, a diagnosis of cow's milk allergy was confirmed by skin test and/or in vitro testing. These 5 patients were treated with replacement of milk using infant formula containing hydrolyzed proteins. This therapy resulted in restoration of normal immunoglobulin values and resolution of gastrointestinal symptoms. The authors alert us to the fact that hypogammaglobulinemia during early childhood can be secondary to IgE-mediated cow's milk allergy. All of these children showed increased gastrointestinal clearance of alpha-1 antitrypsin, thus suggesting that the hypogammaglobulinemia resulted from enzyme-link via the inflamed gastrointestinal mucosa. Reference Bezrodnik A, Raccio A, Canil L, et al., Immunology 2007; 122:140-146   BACK
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