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Allergy & Asthma Advocate: Summer 2005
The studies summarized below appeared in the June and July 2005 issues of the Journal of Allergy and Clinical Immunology (JACI), the peer-reviewed scientific journal of the American Academy of Allergy, Asthma & Immunology.
Intervention program reduces asthma in children
An asthma intervention program applied during the first year of life significantly reduced the prevalence of asthma in high risk children at 7 years of age, according to findings in the July 2005 Journal of Allergy & Clinical Immunology (JACI).
Moira Chan-Yeung, MB, and colleagues from the Canadian Childhood Asthma Prevention Study, studied high risk infants with an immediate family history of asthma and allergies. The children were assigned to either a study or control group.
In the study group, intervention measures were introduced before birth and during the first year of life. These included avoidance of house dust mites, pets and secondhand smoke, encouragement of breast feeding, and delayed introduction of solid foods during the first 12 months of life.At age seven, 469 children completed a questionnaire asking about respiratory symptoms, and the frequency, severity and medication for treatment of wheezing attacks in the last 12 months. Three hundred eighty of the children returned for further assessment by a pediatric allergist and underwent breathing tests to determine the degree of airway hyperresponsiveness, a typical feature of asthma.
The study found that the intervention measures significantly reduced the frequency of asthma by 56%. The prevalence of asthma was significantly lower in the intervention group than in the control group (14.9% vs. 23%).
Researchers hypothesized that an intervention during the first year of life has the potential for long-term medication of an infants risk for asthma development. They plan to assess the children at 11 to 12 years to determine whether the intervention program can be effective in decreasing the lifelong risk for asthma or if it has merely postponed the onset of the disease.Day care facilities an important source for common indoor allergens
Day care facilities were shown to be an important source for allergen exposure, according to a study featured in the July 2005 Journal of Allergy & Clinical Immunology (JACI).
Indoor allergies have been associated with an increased risk of allergy and asthma development in children. Many studies have examined this relationship using levels found in the child’s home since this is where they typically spend most of their time.
Many children also spend a significant amount of time in day care. In 1997, 63% of the country’s 19.6 million children under the age of five were in some form of regular child care during a typical week. However, little information is known on allergy levels in day care facilities in the United States.
Samuel J. Arbes, DDS, MPH, PhD, and colleagues from the National Institute of Environmental Health Sciences examined the levels of seven indoor allergens (dog, cat, mouse, American and European dust mite, fungus, and cockroach) in 89 day care facilities located in two North Carolina counties. At each facility, researchers administered questionnaires and collected dust samples from the room where children spent the most time. They collected either a carpet sample, hard surfaces sample, or one of each if both were present.
Researchers discovered:
- Detectable levels of each allergen were found in a majority of the day care facilities examined.
- Dog and cat allergen were detected in 97% and 100% of the facilities, even though dogs and cats were not present in the majority of the facilities.
- The highest concentrations were for fungus, American dust mite allergen, and dog and cat allergen.
- The lowest concentrations were for cockroach allergen, European dust mite allergen and mouse allergen.
- Carpeted surfaces had significantly higher levels of dog, cat and dust allergens, indicating that carpets provide a reservoir for these allergens.
Researchers compared the results of the study to results of the National Survey of Lead and Allergens in Housing, which studied allergen concentrations in 831 homes. They found that although levels of these allergens were high enough in some day care facilities to trigger allergy and asthma symptoms, they were very similar to those found in living rooms in the Southern United States.
This study provides evidence that day care settings are an important source of exposure to indoor allergens. Further research should be conducted to examine relationships between allergen exposure in day-care faculties and the effect on the health of children and day-care workers.
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