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Teaching Curriculum: Clinical Immunology
Priorities:
Pediatrics 2, Internal Medicine 1
Family Practice 3, Student 3
OBJECTIVES
- Upon completion of this rotation the rotator should be able to:
- List functions of Th1, Th2, and B cells
- Describe briefly the interaction between T cells, B cells and macrophages
- Describe the various classes of immunoglobulins and their functions
- Discuss functions of IgG subclasses and their use in diagnosis of immunodeficiency
- Discuss the use of functional antibody assays in the diagnosis of humoral immune deficiency
- List the components of the complement system and disorders associated with deficiency of C1INH, early classical pathway components, late classical pathway components
- Explain the major steps of phagocytosis
- List two diseases with phagocytic dysfunction
- Describe the cytokines, interleukins, and interferons available for clinical use and indications for use of these modalities
- Classify immunodeficiency diseases including:
- B cell immunodeficiency diseases
- T cell immunodeficiency diseases
- combined B cell and T cell immunodeficiency diseases
- For the immunodeficiency states above describe:
- common presenting signs and symptoms
- common physical findings
- types of organisms typically causing infection in these patients
- differential diagnoses of
- recurrent respiratory tract infections, including cystic fibrosis, IgE-mediated processes, air pollution exposure, anatomic abnormalities, etc.
- recurrent sepsis and/or meningitis
- recurrent soft-tissue, bone, and joint bacterial infections
- List three laboratory methods to identify deficiency of antibody-mediated immunity
- List two methods for screening for cell-mediated immunity
- List two laboratory test methods for screening for phagocytic deficiency
- List the laboratory tests for screening of complement deficiency
- List three laboratory tests for screening for autoimmune disease.
- List common systemic presentations for the major autoimmune diseases in childhood (for pediatrics), adolescence (for all), and adulthood (for internal medicine)
- List three laboratory methods of screening for HIV disease
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