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JACI Highlights - March 2007

Lee et al – Contamination of probiotic preparations with milk allergens can cause anaphylaxis in cow’s milk allergic children

Probiotics are often used to prevent early childhood atopic diseases but a recent study suggests it may carry a risk for children with cow’s milk allergies. In the March 2007 issue of the Journal of Allergy and Clinical Immunology, Lee and colleagues report on probiotic preparations and the incidence of milk allergen contamination. The authors recently reported a case of an infant with cow’s milk allergy who had an allergic reaction 15 minutes after ingesting a probiotic supplement. They have subsequently tested several probiotic preparations commonly used in France in a cohort of children with allergies to cow’s milk. Their findings show that 2 out of 3 of the probiotic preparations contained significant amounts of cow’s milk allergen. Probiotic providers should establish production procedures that eliminate food allergens from their products, evaluate residual allergen content in their preparations, and indicate on the label the characteristics of the culture medium.

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