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JACI Highlights - March 2007
Devouassoux et al – Sleep apnea is associated with bronchial inflammation and continuous positive airway pressure-induced airway hyperresponsiveness
In the March 2007 issue of the Journal of Allergy and Clinical Immunology, Devouassoux and colleagues study whether bronchial inflammation occurs in patients with obstructive sleep apnea and the effects of nasal Continuous positive airway pressure (CPAP) treatment on bronchial inflammation. They found the presence of bronchial inflammation in non-smoking patients with Obstructive Sleep Apnea Syndrome (OSA). Following one month of treatment with CPAP, the first line therapy of sleep apnea, there was no change in airway inflammation but the degree of airway responsiveness to methacholine was increased. Further investigation is needed to analyze the long-term impact of inflammation and CPAP on lung function particularly in at-risk patients.
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