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JACI Highlights - March 2007
De Marco et al – Inhaled steroids are associated with reduced lung function decline in asthmatics with elevated total IgE
Patients with asthma have accelerated decline in lung function compared with non-asthmatics. In more severe asthma, this may result in irreversible airflow obstruction. In the March 2007 issue of the Journal of Allergy and Clinical Immunology, De Marco and colleagues evaluate whether use of inhaled steroids affects this lung function decline. The found that prolonged treatment with inhaled steroids is associated with less decline in lung function in subjects with asthma who had elevated IgE levels. This association was not seen in those with normal IgE levels. These findings underline the importance of total IgE as a feature of asthma because it might influence decisions on long-term anti-inflammatory treatment.
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