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JACI Highlights - February 2007
van Ree et al - Indoor allergens: relevance of major allergen measurements and standardization
In the February 2007 issue of the Journal of Allergy and Clinical Immunology, van Ree and colleagues discuss the relevance of major allergen measurements and standardization for prevention and treatment of allergic diseases. To design adequate dosage schemes and elucidate the dose-response relation between major allergen dose and therapeutic effect, it is necessary to add major allergen measurements to standardization requirements. The authors conclude that to facilitate comparability, standardization should be based on certified major allergen references and accompanying assays that are cross-reactive enough to recognize all variants. Future regulations for immunotherapy products should include major allergen measurements in addition to biological standardization. Measures to control indoor allergen exposure as strategy to prevent allergy will also benefit from such improvements in the field of allergen standardization by ensuring that the results from different epidemiological surveys are comparable.
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