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JACI Highlights - February 2007

Kerzl - Life-threatening anaphylaxis to kiwi fruit: Protective sublingual allergen immunotherapy effect persists even after discontinuation

In the February 2007 issue of the Journal of Allergy and Clinical Immunology, Mempel and colleagues studied the effect of sublingual immunotherapy (SLIT) on a case of anaphylactic kiwi allergy. SLIT has been shown to reduce clinical symptoms in a variety of IgE-mediated respiratory allergic diseases, but its therapeutic value in anaphylactic food allergy is often questioned due to lack of standardized protocols and the great variability in allergen uptake by "custom-made" protocols. The authors found that when given SLIT for kiwi allergy, the patient experienced no symptoms. Even when SLIT was interrupted for a brief period due to other medical conditions, when it was resumed, the effects were still the same. The authors' findings show that the use of SLIT protocols for patients with food allergies should be encouraged, especially when the foods are difficult to avoid.

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