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JACI Highlights - February 2007
Gibson et al - Differential effects of maintenance long-acting beta-agonist and inhaled corticosteroid on asthma control and asthma exacerbations
In the February 2007 issue of the Journal of Allergy and Clinical Immunology, Gibson and colleagues compared and contrasted the efficacy and safety of long-acting beta-agonists/inhaled corticosteroids against different maintenance inhaled corticosteroid strategies in adults with asthma. Combination therapy with inhaled corticosteroids and long-acting beta-agonists has become established as effective maintenance treatment for asthma; however, the use of long-acting beta-agonists with inhaled corticosteroids is recommended when asthma is inadequately controlled by inhaled corticosteroids alone. The authors found that the addition of long-acting beta-agonist to inhaled corticosteroids reduced the risk of asthma exacerbations when compared to a similar inhaled corticosteroid dose, and the combination also led to significant improvements in asthma control when compared to all three maintenance inhaled corticosteroid strategies. The authors' findings show that the greatest benefit and least harm of long-acting beta-agonists comes when they are added to a similar inhaled corticosteroid dose in adults with symptomatic asthma.
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