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JACI Highlights - January 2007
Martin et al – Predicting response to inhaled corticosteroid efficacy (PRICE Trial)
In the January 2007 issue of the Journal of Allergy and Clinical Immunology, Martin and colleagues evaluate characteristics of asthma which may predict how patients responsd to inhaled corticosteroid treatment. National and international guidelines recommend anti-inflammatory therapy for treatment of chronic asthma. However, an increasing number of studies suggest that 25-35% of asthmatics may not improve lung function with inhaled corticosteroids, the preferred anti-inflammatory therapy. The authors found that the short term response to inhaled corticosteroids leading to improvement in forced expiratory volume in one second (FEV1) appears to predict long term asthma control. The decision to use inhaled steroids on a long term basis could therefore be based on a short term trial.
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