Published Online: December 12, 2015
The severity of allergic reactions can range from mild to severe. The most severe allergic reaction, anaphylactic shock, is a potentially lethal condition. There is an evident increase in the overall incidence of allergic reactions, but little has been reported regarding time trends of anaphylactic shock.
In a recent issue of The Journal of Allergy and Clinical Immunology
(JACI), Jeppesen et al. report the rates of hospitalization for anaphylactic shock during an 18-year period, the proportion of anaphylactic shock patients admitted to an intensive care unit, and the prognosis. They conducted a cohort study including 6707 patients hospitalized with anaphylactic shock between 1995 and 2012 during 103,747,997 person-years of observation time using nationwide population-based registries in Denmark.
The study found an overall anaphylactic shock hospitalization rate of 65 per 1,000,000 person-years and noted an overall two-fold increase from 1995 through 2012, but in children the increase was ten-fold. The percentage admitted to an intensive care unit did not change over time and below 1% of the anaphylactic shock patients died within 30 days after the diagnoses.
The authors concluded that more research is needed to understand the cause behind the increase in anaphylactic shock hospitalization rates.
The Journal of Allergy and Clinical Immunology
(JACI) is an official scientific journal of the AAAAI, and is the most-cited journal in the field of allergy and clinical immunology.