Q:

7/15/2014
It is reported epinephrine is both heat AND light sensitive, and perhaps an airport x-ray has unknown potential to alter the efficacy of the medication. Both Mylan and Sanofi have disclosures in the package insert about safe handling and storage procedures. Is there a concern taking auto injectable epinephrine thru TSA x-ray machines or should patients be asking for a "visual screening" only?

A:

Thank you for your inquiry.

I could find no information on this topic whatsoever on a literature search and therefore cannot give you an answer. However, I am going to consult Dr. Keith Simons, who is an international expert in the pharmacokinetics and pharmacodynamics of epinephrine. If Dr. Simons has any further knowledge in this regard, we will forward his response to you.

Thank you again for your inquiry.

Sincerely,
Phil Lieberman, M.D.

Dr. Keith Simons has responded to your inquiry with a reference (1) which looked at the effect of varying doses of ionizing radiation on drugs used for patients requiring advanced life support. Epinephrine was one of these drugs.

They employed varying doses of radiation over several periods of time and concluded that ionizing radiation "does not alter the potency or shelf life of epinephrine".

Thank you again for your inquiry, and we hope this is of help.

Sincerely,

Phil Lieberman, M.D.

Reference:
Sullivan DJ, et al. The effect of ionizing radiation on advanced life support medications. Annals of Emergency Medicine 1987; 16(6): 662-665.

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