What is the relation between total IgE level and specific IgE level? Does decreasing total IgE level to normal value entail normal value of specific IgE?


Thank you for your inquiry.

Specific IgE refers to IgE directed against a specific allergen. For example, specific IgE may be the amount of IgE that is directed against ragweed. The total IgE is the sum of all the specific IgE. It is not IgE directed against a specific allergen, but is the measurement of all the allergen-specific IgE. There is no “normal” value for a specific IgE. The “normal” value is only for total IgE. If one decreases total IgE, various specific IgE values could be decreased equally or there might simply be a decrease in a single specific IgE.

Thank you again for your inquiry and we hope this response is helpful to you.

Phil Lieberman, M.D.

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AAAAI - American Academy of Allergy Asthma & Immunology