Is ibuprofen skin-testable, though it's hypersensitivity if related to imbalances in prostaglandin and arachidonic acid metabolisms? Has it been done in the past? My guess is probably not, since it is not an IgE mediated reaction, like the other NSAIDs.


Thank you for your inquiry.

Reactions to nonsteroidal antiinflammatory drugs occur through different mechanisms. The mechanism involving arachidonic acid metabolism accounts for reactions to nonsteroidal antiinflammatory drugs such as ibuprofen in patients who have aspirin-exacerbated respiratory disease (chronic sinusitis, nasal polyps, and aspirin sensitivity). However, other types of reactions such as anaphylaxis and urticaria can occur to ibuprofen. These can be drug-specific or class-specific. It is conceivable that these may be IgE-mediated, but no test to date has confirmed this to my knowledge.

So in direct answer to your question, there is no validated skin test to ibuprofen.

Thank you again for your inquiry and we hope this response is helpful to you.

Phil Lieberman, M.D.

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