Progesterone Allergy Question: 2/28/2017 I am looking for a protocol for progesterone skin test and desensitization. Answer: I have found several articles in the literature which could help guide you in evaluating a patient with suspected progesterone hypersensitivity. The first two articles reference skin testing and progesterone and the latter two articles provide some guidance for desensitization to progesterone. I hope this is helpful. 1) Allergy Asthma Immune Res 2011 April 3(2): 141-144 2) Clinical and Molecular Allergy 2004, 2: 10 3) Fertil Steril. 2011 Mar 1;95(3):1121.e9-13 4) Chronic idiopathic urticaria exacerbated with progesterone therapy treated with a novel desensitization protocol I hope this has been helpful. Andrew Murphy, MD FAAAAI