I currently treat a patient with moderate asthma and allergic rhinitis with allergen immunotherapy and Xolair in addition to medications including ICS/LABA inhaler and oral antihistamines. The patient would like to try Otezla (Apremilast), a new PDE4 inhibitor to treat her psoriasis. Do you know of any contraindication to using omalizumab with a PDE4 inhibitor?


Thank you for your inquiry.

I know of no contraindication to the concomitant use of apremilast and omalizumab, and could find none in a review of the literature or the package inserts of these agents.

Thank you again for your inquiry and we hope this response is helpful to you.

Phil Lieberman, M.D.

Ask A Question

Healthcare Professionals: If you can’t find what you are looking for, please send us your question.

Due to the number of questions submitted to Ask the Expert, we are experiencing a significant delay in responses at this time.

Ask now

AAAAI - American Academy of Allergy Asthma & Immunology