You had stated last year that you would inquire with Tim Sullivan whether there was any validated skin test or challenge protocol to statins. I have a pt who had throat tightness 10 years ago and I was going to bring her in for a graduated challenge but was curious if the were some sort of protocol or skin testing available. Thanks.


Thank you for your inquiry.

There was no desensitization or oral challenge protocol to statins that I could find in the literature at the time of the last inquiry to our website regarding this issue. However, recently a successful desensitization to rosuvastatin (1) was reported. The article contains a desensitization protocol which you can employ exactly should you choose to desensitize to rosuvastatin. Alternatively, you could model a challenge/desensitization protocol to another statin based upon equivalent dosage calculations.

Thank you again for your inquiry and we hope this response is helpful to you.

1. Khan FS, et al. Successful desensitization to rosuvastatin in a patient with a history of anaphylaxis to multiple statins. J Allergy Clin Immunol 2013 (January); 131(1):234-236.

Phil Lieberman, M.D.

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